Sodium Hydroxide → HCID 53721136, compound

Participants

Reaction Steps

To a solution of 8.95 g (29.3 mmol) of Part (3) compound in 90 mL of absolute ethanol cooled in an ambient water bath was added 90 mL of 1N aq NaOH solution. The reaction mixture was stirred for 16 h then concentrated in vacuo to ~1/2 volume to remove ethanol. The residue was partitioned between 100 mL of 1M aq HCl solution and 100 mL of ether. The aqueous layer was separated and extracted with two-50 mL portions of ether. The ether extracts were combined, dried (magnesium sulfate) and concentrated in vacuo to afford 8.15 g (29.4 mmol, 100%) of title compound as a colorless oil.

Provenance & Evidence