Sodium Hydroxide → HCID 18953781, compound

HRID 1491878Notes

Reaction equation

HRID 1491878 reaction equation
Cl.Cl.[NH2:3][C:4]1[N:9]=[C:8]([C:10]2[N:11]=[C:12]([N:15]=[C:16]([NH2:18])[NH2:17])[S:13][CH:14]=2)[CH:7]=[CH:6][CH:5]=1.[OH-].[Na+]>O>[NH2:3][C:4]1[N:9]=[C:8]([C:10]2[N:11]=[C:12]([N:15]=[C:16]([NH2:17])[NH2:18])[S:13][CH:14]=2)[CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18953872HCID 18953872, compound

Product 1

HCID 18953781HCID 18953781, compoundYield 94.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 4-(6-aminopyridin-2-yl)-2-(diaminomethyleneamino)thiazole dihydrochloride (5.0 g) in water (50 ml) was adjusted to pH 11 with 5N-sodium hydroxide and the mixture was extracted with a mixture of tetrahydrofuran and ethyl acetate. The extract layer was washed with brine, dried over magnesium sulfate and evaporated in vacuo to give 4-(6-aminopyridin-2-yl)-2-(diaminomethyleneamino)thiazole (3.62 g).

Workup

  1. extractionthe mixture was extracted with a mixture of tetrahydrofuran and ethyl acetate
  2. washThe extract layer was washed with brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-1b0ddfb64ee5403fabbb2fd76cc7c1ab
Source dataset
uspto-grants-1994_12
Patent number
US05371097

Reaction notes

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