HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1491930Generated: October 31, 2026
Sodium Iodide → 3-(4-(1-(1,1-dioxo-1,2-Benzisothiazol-3-yl)-4-piperazinyl)butyl)-1-thia-3-azaspiro[4.4]nonan-4-one
https://huagongshe.com/reaction/1491930
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(Piperazin-1-yl)-1,2-benzothiazole-1,1-dione | HCID 695718 | — |
| Reactant | 3-(4-Bromobutyl)-1-thia-3-azaspiro[4.4]nonan-4-one | HCID 10708747 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-(4-(1-(1,1-dioxo-1,2-Benzisothiazol-3-yl)-4-piperazinyl)butyl)-1-thia-3-azaspiro[4.4]nonan-4-one | HCID 10576037 | 52.2% |
Reaction Steps
A mixture of 3-(4-bromobutyl)-1-thia-3-azaspiro[4.4]-nonan-4-one (3.50 g), 1-(1,1-dioxo-1,2-benzisothiazol-3-yl)piperazine (3.30 g), K2CO3 (4.98 g) and NaI (280 mg) in acetonitrile (230 ml) was heated at 85° C. for 20 hours and the product was processed in substantially the same manner as in Example 10 to afford 2.89 g of needles, m.p. 137°-140° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05371087 |
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| Source dataset | uspto-grants-1994_12 |
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| ORD ID | ord-3d8a2492194f4c47948a38d45ca5ca50 |
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| Source note | uspto-grants-1994_12 |
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