HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 18954274, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-[(4-Aminophenyl)methyl]-3,4-dihydro-2(1H)-quinolinone | HCID 16783324 | — |
| Reactant | HCID 19349812 | HCID 19349812 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 18954274 | HCID 18954274 | — |
Reaction Steps
A mixture of 2.52 g of 1-p-aminobenzyl-1,2,3,4-tetrahydro-2-oxoquinoline, 3 ml of triethylamine, 0.5 g of 4-dimethylaminopyridine and 120 ml of methylene chloride is cooled to 5° and a solutoin of 2.88 g of o-trifluoromethanesulfonamidobenzoyl chloride in 20 ml of methylene chloride is added dropwise. The mixture is stirred for a further 16 hours at 20°, evaporated and worked up in conventional manner to give 1,2,3,4-tetrahydro-2-oxo-1-[4-(2-trifluoromethanesulfonamidobenzamido)benzyl]quinoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05371226 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-024fd9190e7e4b2190e7ab9265f212db |
| Source note | uspto-grants-1994_12 |