Ethanol → [(E)-3-[4-chloro-3-(trifluoromethyl)phenyl]prop-2-enoyl]-oxidoazanium

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Reaction Steps

12.1 g (0.05 mol) of 4-chloro-3-trifluoromethyl-cinnamonitrile are added to a solution of 7.2 g (0.10 mol) of hydroxylamine hydrochloride, 7.3 g (0.10 mol) of sodium carbonate in 100 ml of water, and 100 ml of ethanol. The mixture is refluxed until the reaction is complete (24 hours) and the entire batch is subsequently stirred into 250 ml of water. The solid which separates out during this process is filtered off with suction, washed with a little water and dried. 5.3 g (39.3% of theory) of (E)-4-chloro-3-trifluoromethyl-cinnamamide oxide are obtained.

Provenance & Evidence