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Sulfuryl chloride → (2E)-2-[2-(4-chlorophenoxy)phenyl]-2-methoxyimino-N-methylacetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuryl chloride | HCID 24648 | — |
| 反応物 | (2E)-2-methoxyimino-N-methyl-2-(2-phenoxyphenyl)acetamide | HCID 5483872 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (2E)-2-[2-(4-chlorophenoxy)phenyl]-2-methoxyimino-N-methylacetamide | HCID 19429863 | 68.1% |
反応手順
A solution of (E)-N-methyl-2-(2-phenoxyphenyl)-2-methoxyiminoacetamide (500 mg) in dichloromethane was cooled to 0° C., and sulfuryl chloride (285 mg) was dropwise added thereto. The resultant mixture was stirred at the same temperature for 2 hours, diluted with water and extracted with diethyl ether. The solvent was dried and removed, and the residue was subjected to HPLC with a mixture of hexane and ethyl acetate to give 382 mg of the objective compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05371222 |
| 出典データセット | uspto-grants-1994_12 |
| ORD ID | ord-e1b54a6892ab41e7b12785ca4b4efe79 |
| 出典メモ | uspto-grants-1994_12 |