Diethyl Ether → HCID 18953733, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 18.96 g (0.12 mole) of 3-bromopyridine in 50 ml of ether is added dropwise into a 54.72 ml (0.11 mole) of 2.01M n-butyllithium in hexane in 550 ml of ether at -78° C. with stirring under argon over a period of 20 min. The mixture is stirred for another 1/2 h and a solution of 30.35 g (0.0902 mole) of 2-[3-(2-methoxyethoxymethoxy)propyl]-2-(2-methoxyethoxymethoxy)-γ-butyrolactone in 30 ml of ether is added dropwise over a period of 10 min. The mixture is stirred at -78° C. for 2 h, allowed to warm up to -20° C., quenched with 15 ml of saturated aqueous ammonium chloride and washed with water and brine. The ether layer is dried (MgSO4) and evaporated to give 2,5-bis-(2-methoxyethoxymethoxy)-3-nicotinoyl-hexan-1-one as an oil.

Provenance & Evidence