HCID 86748310, compound → HCID 57126774, compound

Participants

Reaction Steps

A solution of 6.7 g (0.0184 mol) of methyl (E)-(2S,3S,4S)-3-[4-(t-butyldimethylsilyloxy)-2-(3-pyridyl)tetrahydrofuran-3-yl]-2-propenoate in 94 mL of ethanol is hydrogenated over 0.7 g of 10% palladium on carbon catalyst at atmospheric pressure. The catalyst is filtered, washed with ethanol and the filtrates are evaporated to dryness to give methyl (2S,3S,4S)-3-[4-(t-butyl-dimethylsilyloxy)-2-(3-pyridyl)tetrahydrofuran-3-yl]propanoate as an oil with elemental analysis: C, 62.77; H, 8.35: N, 3.84 (theory: C, 62.43: H, 8.55: N, 3.83).

Provenance & Evidence