Imidazole → HCID 18953767, compound

Participants

Reaction Steps

A solution of 4.59 g (0.0256 mole) of 5-hydroxy-1-(3-pyridyl)pentan-1-one, 3.82 g (0.0561 mole) of imidazole 7.76 g (0.0282 mole) of tert-butyldiphenylsilylchloride in 10 ml of dimethylformamide is stirred at room temperature for 15 h, diluted with 75 ml of water and extracted with ethyl acetate (2×50 ml). The extracts are washed with water and brine, dried (MgSO4) and evaporated. The residue is purified by flash chromatography using methylene chloride-ethyl acetate (4:1) as eluent to give 5-(t-butyldiphenylsilyloxy)-1-(3-pyridyl)pentan-1-one as an oil.

Provenance & Evidence