Sodium Hydroxide → 1-methyl-4-(trifluoromethyl)-1H-pyrrole-3-carboxylic acid

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Reaction Steps

A mixture of ethyl 1-methyl-4-(trifluoromethy1)pyrrole-3-carboxylate (4.4 g, 0.02 mol) and 4N sodium hydroxide (5 ml, 0.02 mol) in ethanol is stirred for 24 hours at room temperature, diluted with water and extracted with ether. The aqueous phase is acidified with 10% HCl and filtered. The filter cake is washed with water and dried in vacuo at 45° C. to afford the title compound as an off-white solid, 2.4 mp 210° to 212° C.

Provenance & Evidence