HCID 14405001, compound → HCID 14405003, compound

HRID 1492070Notes

Reaction equation

HRID 1492070 reaction equation
[Cl:1][C:2]1[C:7]([F:8])=[C:6]([N+:9]([O-])=O)[C:5]([F:12])=[C:4]([Cl:13])[C:3]=1[OH:14].[H][H]>CO.[Ni]>[Cl:1][C:2]1[C:7]([F:8])=[C:6]([NH2:9])[C:5]([F:12])=[C:4]([Cl:13])[C:3]=1[OH:14]

Participants

5

Reactant 2

HCID 14405001HCID 14405001, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 14405003HCID 14405003, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

18 g of 2,6-dichloro-3,5-difluoro-4-nitrophenol are hydrogenated in 100 ml of methanol in the presence of 1.5 g of Raney nickel at 25°-45° C. using 30-50 bar of hydrogen until the take-up of hydrogen is complete. After filtration, the solution is freed from solvent under reduced pressure. 13 g of aminophenol (GC purity 98.4%) remain; m.p. 151° C.

Workup

  1. filtrationAfter filtration

Sources & evidence

ORD record
ord-db26d9bd82144b47a0a0ac37664e62c9
Source dataset
uspto-grants-1994_12
Patent number
US05371271

Reaction notes

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