Ethanol → HCID 86748307, compound

Participants

Reaction Steps

A method similar to Example 2 was used and 11.8 g (60 mmol) of 1-(2,6-difluorophenyl )-cyclopropanecarboxylic acid, prepared according to Example 8b and dissolved in 60 ml of ethanol, were converted with 3.6 g (64 mmol) of potassium hydroxide to the potassium salt of 2,6-difluorophenylcyclopropanecarboxylic acid, and said salt was then reacted, at 90° C., in 100 ml of N-methylpyrrolidone, with 13.3 g (47 mmol) of 2-(bromomethyl)phenylglyoxylic acid methyl ester O-methyloxime. The resulting oily product was covered with a layer of diisopropyl ether and was crystallized by rubbing the wall of the vessel. Yield: 85%; mp.: 122°-123° C.; white crystals.

Provenance & Evidence