Potassium Hydroxide → HCID 67823835, compound

Participants

Reaction Steps

A solution of 11.0 g (36 mmol) of ethyl 1,2-dimethyl-3,3-dibromocyclopropanecarboxylate (prepared according to Intermediate 12a) and 2.2 g (40 mmol) of potassium hydroxide in 100 ml of ethanol was stirred for 6 hours at 60° C. and then evaporated down. The solution was covered with a layer of diethyl ether, after which the resulting precipitate was separated off and washed with diethyl ether. Subsequent reaction of the resulting potassium salt of dimethyldibromocyclopropanecarboxylic acid in 60 ml of N-methylpyrrolidone with 5.1 g (18 mmol) of methyl alpha- (2-bromomethylphenyl ) -beta-methoxyacrylate was carried out similarly to Example 1. After hydrolysis of the reaction mixture, the product was extracted with methyl tert-butyl ether and was isolated and purified similarly to Example 1. Yield: 32% colorless oil.

Provenance & Evidence