HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1492124Generated: October 26, 2026
Acetic Anhydride → 3',5'-Dichloro-4'-hydroxyacetanilide
https://huagongshe.com/reaction/1492124
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Phenol, 4-amino-2,6-dichloro-, hydrochloride (1:1) | HCID 162059 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3',5'-Dichloro-4'-hydroxyacetanilide | HCID 10082180 | 95% |
Reaction Steps
Into a 500 ml round bottom flask (fitted with a magnetic stirrer), water (200 ml) was mixed with 4-amino-2,6-dichlorophenol hydrochloride (20 g) until the solid was completely dissolved. The resulting solution was warmed to 70° C., and to it was added acetic anhydride (11 g) and the resulting solution was stirred for 1 hour. Upon cooling, crystals of 3', 5'-dichloro-4'-hydroxyacetanilide formed (19.6 g, 95% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05372931 |
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| Source dataset | uspto-grants-1994_12 |
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| ORD ID | ord-6ea95674393a4909b3414ba0354333ad |
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| Source note | uspto-grants-1994_12 |
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