2,6-Lutidine → HCID 18952365, compound

Participants

Reaction Steps

2,6-Lutidine (0.27 mL, 0.248 g, 2.32 mmol) is added to a solution of 4,5-dichloro-8-quinazolinol (0.5 g, 2.33 mmol) in chloroform at ice bath temperature. A solution of bromine in carbontetrachloride (2.4 mL, 1.0 molar) is then added dropwise to the reaction mixture and a precipitate forms. The reaction mixture is diluted with chloroform, washed sequentially with water and saturated NaHCO3 solution, dried over MgSO4 and concentrated in vacuo to give the title product as a yellow solid, 0.7 g, mp 156.5° C. (dec.).

Provenance & Evidence