HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Bromo-4-methyl-4H-pyrido[3,2-b][1,4]oxazin-3-one → 4-[5-fluoro-3-(4-methyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-7-ylthio)phenyl]-4-methoxytetrahydropyran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Bromo-4-methyl-4H-pyrido[3,2-b][1,4]oxazin-3-one | HCID 15925984 | — |
| Reactant | 4-(5-Fluoro-3-mercaptophenyl)-4-methoxytetrahydropyran | HCID 18996287 | — |
| Product | 4-[5-fluoro-3-(4-methyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-7-ylthio)phenyl]-4-methoxytetrahydropyran | HCID 18952069 | 4% |
Reaction Steps
Using the procedure described in Example 11, 7-bromo-4-methyl-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-3-one was reacted with 4-(5-fluoro-3-mercaptophenyl)-4-methoxytetrahydropyran to give 4-[5-fluoro-3-(4-methyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b]-[1,4]oxazin-7-ylthio)phenyl]-4-methoxytetrahydropyran in 4% yield, m.p. 127°-128° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05373007 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-bb436fb8c3cc4988af545af6c677ee36 |
| Source note | uspto-grants-1994_12 |