Lithium Hydroxide → Gavestinel

Participants

Reaction Steps

To a solution of Example 1 (250 mg) in ethanol (2.5 ml), lithium hydroxide (104 mg) was added at 23°. The reaction was stirred at 50° for 6 hours then the solvent was evaporated and the residue dissolved in water (5 ml). The aqueous layer was acidified with 1N hydrochloric acid until a white solid precipitated. The latter was collected by filtration and dried to give the title compound as a white solid (230 mg).

Provenance & Evidence