Carbonic acid-guanidine (1:1) → HCID 21806735, compound

HRID 1492175Notes

Reaction equation

HRID 1492175 reaction equation
[NH:1]1[C:8](=[O:9])[CH2:7][C:5](=[O:6])[NH:4][C:2]1=[S:3].C(=O)(O)O.[NH2:14][C:15]([NH2:17])=[NH:16]>O>[NH:1]1[C:8](=[O:9])[CH2:7][C:5](=[O:6])[NH:4][C:2]1=[S:3].[NH2:16][C:15]([NH2:17])=[NH:14]

Participants

4

Reactant 2

HCID 286947Carbonic acid-guanidine (1:1)HCID 2723628Thiobarbituric acid

Product 1

HCID 21806735HCID 21806735, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

600 g of water and 432 g (3 mol) of thiobarbituric acid (Merck) were heated to 90° C. and 270 g (1.5 mol) of guanidine carbonate (Chemie Linz) were added while stirring. After stirring for a further 2 hours at the boiling point while refluxing, the guanidine thiobarbiturate formed was suction filtered, washed twice with cold water, and dried overnight at 105° C. in a drying cabinet. Guanidine thiobarbiturate was obtained in a yield of 80%. The melting point was 320°-325° C., and the decomposition temperature was above 450° C. The compound was identified by means of its IR spectrum.

Workup

  1. stirringAfter stirring for a further 2 hours at the boiling point
  2. temperaturewhile refluxing

Sources & evidence

ORD record
ord-bc0ee70a535a4051b667c90230d60aea
Source dataset
uspto-grants-1994_12
Patent number
US05373038

Reaction notes

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