HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1492185Generated: October 25, 2026
Isobutyronitrile → N-(2-morpholinophenyl)isobutyramidine
https://huagongshe.com/reaction/1492185
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isobutyronitrile | HCID 6559 | — |
| Reactant | 2-Morpholinoaniline hydrochloride | HCID 18952284 | — |
| Product | N-(2-morpholinophenyl)isobutyramidine | HCID 178449872 | — |
Reaction Steps
A mixture of 4-(2-aminophenyl)morpholine hydrochloride (10 g) and isobutyronitrile (60 ml) was heated at 165° C. for 26 hours in a sealed stainless steel pressure vessel to yield N-(2-morpholinophenyl)isobutyramidine (m.p. 140°-141° C.) which was recrystallised from hexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05373008 |
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| Source dataset | uspto-grants-1994_12 |
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| ORD ID | ord-030dc84115224d40a2f2a3b18cc66c49 |
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| Source note | uspto-grants-1994_12 |
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