HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → N-methyl-N'-(2-morpholinomethylphenyl)pivalamidine monofumarate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | N,2,2-Trimethylpropanamide | HCID 138844 | — |
| Reactant | Fumaric Acid | HCID 444972 | — |
| Reactant | 2-(Morpholin-4-ylmethyl)aniline | HCID 6484555 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-methyl-N'-(2-morpholinomethylphenyl)pivalamidine monofumarate | HCID 178484900 | — |
Reaction Steps
A mixture of N-methylpivalamide (6.2 g) in benzene (50 ml), 4-(2-aminobenzyl)morpholine (9 g) in benzene (40 ml) and phosphorus oxychloride (5 ml) was heated at 80°-85° C. for 12 hours to yield a solid which was dissolved in methanol (25 ml) and treated with fumaric acid (1.4 g) to give N-methyl-N'-(2-morpholinomethylphenyl)pivalamidine monofumarate (m.p. 167°-168° C.) which was recrystallised from propan-2-ol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05373008 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-bc78daeb8565495085fbdfca1d5d0d15 |
| Source note | uspto-grants-1994_12 |