HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 1-Ethyl-2-(2-morpholinophenyl)-1,3,3-trimethylguanidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 2-Morpholinoaniline | HCID 735756 | — |
| Reactant | Urea, ethyltrimethyl-(9CI) | HCID 19962438 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 1-Ethyl-2-(2-morpholinophenyl)-1,3,3-trimethylguanidine | HCID 15746401 | — |
Reaction Steps
Reaction of 3-ethyl-1,1,3-trimethylurea (6.57 g) in benzene (70 ml) with 4-(2-aminophenyl)morpholine (6 g) in benzene (30 ml) in the presence of phosphorus oxychloride (4.71 ml) for 45 hours at 65°-70° C. gave 1-ethyl-2-(2-morpholinophenyl)-1,3,3-trimethylguanidine (bp. 140° C. at 0.2 mm Hg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05373008 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-81646dba97b64883b1500021fadd1290 |
| Source note | uspto-grants-1994_12 |