Phosphorus oxychloride → HCID 86747000, compound

Participants

Reaction Steps

Reaction of 1-methyl-3-(2-methoxyethyl)-2-imidazolidinone (11.4 g) in benzene (60 ml) with 4-(2-aminophenyl)morpholine (8.9 g) in benzene (80 ml) in the presence of phosphorus oxychloride (7.2 ml) for 30 hours at 80°-85° C. gave an oil a portion of which (1.8 g) was dissolved in methanol (10 ml) and treated with fumaric acid (0.9 g) to give 4-{2-[1-methyl-3-(2-methoxyethyl)-2-imidazolidinylideneamino]phenyl}morpholine monofumarate (m.p. 127°-129° C.) which was recrystallised from propan-2-ol.

Provenance & Evidence