Sodium Hydroxide → HCID 15746361, compound

Participants

Reaction Steps

Reaction of 4-{2-[1-methyl-3-(2-acetoxyethyl)-2-imidazolidinylideneamino]phenyl}morpholine (2.7 g) in dimethylformamide (10 ml) with sodium hydroxide (0.4 g) in water (10 ml) for one hour at 10° C. gave an oil which was dissolved in methanol (10 ml) and treated with fumaric acid (0.4 g) to give 4-{2-[1-methyl-3-(2-hydroxyethyl)-2-imidazolidinylideneamino]phenyl}morpholine (m.p. 129°-131° C.) which was recrystallised from a 1:2 mixture of methanol and ether.

Provenance & Evidence