Acetone → HCID 178503975, compound

HRID 1492220Notes

Reaction equation

HRID 1492220 reaction equation
[N:1]1([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[NH:12][C:13]([NH2:15])=[S:14])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:16]C(C)=O.C[I:21]>CO>[IH:21].[CH3:16][S:14][C:13](=[NH:15])[NH:12][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[N:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

5

Reactant 3

HCID 180AcetoneHCID 6328Methyl iodideHCID 15746484HCID 15746484, compound

Product 1

HCID 178503975HCID 178503975, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 1-[2-(1-pyrrolidinyl)phenyl]thiourea (12.2 g), acetone (100 ml) and methanol (20 ml) was heated to 90°-95° C. Methyl iodide (8.36 g) was added and the mixture heated under reflux for 3 hours. The solvent was removed by evaporation to give a residue which was dried under vacuum (5 mm/Hg) to give 2-methyl-1-[2-(1-pyrrolidinyl)phenyl]-2-thiopseudourea hydroiodide (m.p. 139°-141° C.).

Workup

  1. temperaturewas heated to 90°-95° C
  2. temperaturethe mixture heated
  3. temperatureunder reflux for 3 hours
  4. customThe solvent was removed by evaporation
  5. customto give a residue which
  6. customwas dried under vacuum (5 mm/Hg)

Sources & evidence

ORD record
ord-62a7ecf86eae478189585599e96ba25a
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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