Methyl iodide → HCID 178503976, compound

HRID 1492225Notes

Reaction equation

HRID 1492225 reaction equation
[N:1]1([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[NH:13][C:14]([NH2:16])=[S:15])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:17][I:18]>CO>[IH:18].[CH3:17][S:15][C:14](=[NH:16])[NH:13][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[N:1]1[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 15746490HCID 15746490, compound

Product 1

HCID 178503976HCID 178503976, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 1-(2-piperidinophenyl)thiourea (10.1 g), methyl iodide (5.35 g) and methanol (50 ml) was heated at 50°-55° C. for 2 hours. The solvent was removed by evaporation and the residue dried under vacuum (5 mm/Hg) to give 2-methyl-1-(2-piperidinophenyl)-2-thiopseudourea hydroiodide (m.p. 160°-162° C.).

Workup

  1. temperaturewas heated at 50°-55° C. for 2 hours
  2. customThe solvent was removed by evaporation
  3. customthe residue dried under vacuum (5 mm/Hg)

Sources & evidence

ORD record
ord-bff9324c4a2f480fa3307a989d686727
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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