2,3-Butanediamine → HCID 178433115, compound

HRID 1492230Notes

Reaction equation

HRID 1492230 reaction equation
I.CS[C:4](=[NH:18])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.[CH3:19][CH:20](N)[CH:21]([CH3:23])[NH2:22]>C(O)C>[CH3:23][CH:21]1[CH:20]([CH3:19])[NH:18][C:4](=[N:5][C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[NH:22]1

Participants

4

Reactant 2

HCID 1363622,3-ButanediamineHCID 178503978HCID 178503978, compound

Product 1

HCID 178433115HCID 178433115, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-methyl-1-(2-morpholinophenyl)-2-thiopseudourea hydroiodide (7.6 g prepared as described in Example 166), 1,2-dimethylethylenediamine (5.3 g) and ethanol (90 ml) was heated under reflux for 70 hours to give a solid which was recrystallised from ethylacetate to give 4-[2-(4,5-dimethyl-2-imidazolidinylideneamino)phenyl]morpholine (m.p. 142°-143° C.).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 70 hours
  3. customto give a solid which
  4. customwas recrystallised from ethylacetate

Sources & evidence

ORD record
ord-b4eedda357be471bac62a153aad946a5
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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