Methyl isothiocyanate → HCID 8625249, compound

HRID 1492235Notes

Reaction equation

HRID 1492235 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.[CH3:14][N:15]=[C:16]=[S:17]>ClCCl>[O:11]1[CH2:12][CH2:13][N:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[NH:1][C:16]([NH:15][CH3:14])=[S:17])[CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 7357562-Morpholinoaniline

Product 1

HCID 8625249HCID 8625249, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 4-(2-aminophenyl)morpholine (5.3 g) in dichloromethane (25 ml) was treated with methyl isothiocyanate (3.2 g) and the mixture stirred at room temperature for 36 hours to yield 1-(2-morpholinophenyl)-3-methylthiourea (m.p. 115°-116° C.) which was recrystallised from a 4:1 mixture of ethyl acetate and hexane.

Sources & evidence

ORD record
ord-5d01906540cd4da1a1d5ffbe0083c16a
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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