Methylamine → HCID 178449171, Verbindung

HRID 1492242Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1492242
I.CS[C:4](=[N:18][CH2:19][CH2:20][CH2:21][CH3:22])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.[CH3:23][NH2:24]>C(O)C>[CH2:19]([NH:18][C:4]([NH:24][CH3:23])=[N:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)[CH2:20][CH2:21][CH3:22]

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 189521352-Methyl-3-(n-butyl)-1-(2-morpholinophenyl)-2-thiopseudourea hydroiodide

Produkt 1

HCID 178449171HCID 178449171, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 2-methyl-3-(n-butyl)-1-(2-morpholinophenyl)-2-thiopseudourea hydroiodide (4.0 g) and 33% methylamine in absolute ethanol solution (200 ml) was heated initially for 24 hours at 45° and then left at room temperature for 21 days to yield 1-(n-butyl)-2-(2-morpholinophenyl)-3-methylguanidine as an oil; a solution of which in methanol (25 ml) on treatment with fumaric acid (0.7 g) gave a colourless solid which was recrystallised from a 1:1 mixture of methanol and ether to give 1-(n-butyl)-2-(2-morpholinophenyl)-3-methylguanidine monofumarate (m.p. 170°-172° C.).

Aufarbeitung

  1. temperaturewas heated initially for 24 hours at 45°

Quellen und Nachweise

ORD-Eintrag
ord-681f97d68f5b492692aed53503172c14
Quelldatensatz
uspto-grants-1994_12
Patentnummer
US05373008

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