Butylamine → HCID 178449172, compound

HRID 1492249Notes

Reaction equation

HRID 1492249 reaction equation
I.CS[C:4](=[N:18][CH2:19][CH3:20])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.[CH2:21]([NH2:25])[CH2:22][CH2:23][CH3:24]>C(O)(C)(C)C>[CH2:21]([NH:25][C:4]([NH:18][CH2:19][CH3:20])=[N:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)[CH2:22][CH2:23][CH3:24]

Participants

4

Reactant 2

HCID 8007ButylamineHCID 18952330HCID 18952330, compound

Product 1

HCID 178449172HCID 178449172, compound

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

A mixture of 2-methyl-1-(2-morpholinophenyl)-3-ethyl-2-thiopseudourea hydriodide (10 g prepared as described in Example 212), n-butylamine (2.7 g) and t-butanol (75 ml) was heated at 90°-95° C. for 172 hours to yield 1-(n-butyl)-2-(2-morpholinophenyl)-3-ethylguanidine which was converted into its monofumarate salt (m.p. 159°-160° ) which was recrystallised from a 1:2 mixture of methanol and ether.

Workup

  1. temperaturewas heated at 90°-95° C. for 172 hours

Sources & evidence

ORD record
ord-3ad059270c8d42d8912e8dcfc1248805
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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