Methyl isothiocyanate → HCID 18952224, compound

HRID 1492256Notes

Reaction equation

HRID 1492256 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1.[CH3:15][N:16]=[C:17]=[S:18]>ClCCl>[CH3:15][NH:16][C:17]([NH:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:10][CH2:11][O:12][CH2:13][CH2:14]1)=[S:18]

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 18952141HCID 18952141, compound

Product 1

HCID 18952224HCID 18952224, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 4-(2-amino-4-methylphenyl)morpholine (5.7 g) in dichloromethane (30 ml) was treated with methylisothiocyanate (2.8 g) and the reaction mixture kept at room temperature for 6 days to yield 1-methyl-3-(5-methyl-2-morpholinophenyl)thiourea as a colourless solid (m.p. 107° C.).

Sources & evidence

ORD record
ord-5004ba69420e48f8b11f6ad9a5cb55ad
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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