Methyl iodide → HCID 18952101, compound

HRID 1492263Notes

Reaction equation

HRID 1492263 reaction equation
[CH3:1][NH:2][C:3]([NH:5][C:6]1[C:11]([CH3:12])=[CH:10][CH:9]=[CH:8][C:7]=1[N:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1)=[S:4].[CH3:19][I:20]>CC(C)=O>[IH:20].[CH3:19][S:4][C:3](=[N:2][CH3:1])[NH:5][C:6]1[C:11]([CH3:12])=[CH:10][CH:9]=[CH:8][C:7]=1[N:13]1[CH2:14][CH2:15][O:16][CH2:17][CH2:18]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 18952274HCID 18952274, compound

Product 1

HCID 18952101HCID 18952101, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of N-methyl-N'-(6-methyl-2-morpholinophenyl)thiourea (11.5 g), methyl iodide (6.75 g) and acetone (100 ml) was heated under reflux for 2.5 hours to give 2-methyl-1-(6-methyl-2-morpholinophenyl)-3-methyl-2-thiopseudourea hydroiodide (m.p. 187°-188° C.).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 2.5 hours

Sources & evidence

ORD record
ord-fe4774edc69849b2bf919d1a17450ef0
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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