Thiophosgene → HCID 18952335, compound

HRID 1492267Notes

Reaction equation

HRID 1492267 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][C:8]=2[NH2:9])[CH2:3][CH2:2]1.[C:18](Cl)(Cl)=[S:19]>O1CCOCC1.O>[O:1]1[CH2:2][CH2:3][N:4]([C:7]2[CH:13]=[CH:12][C:11]([C:14]([F:16])([F:17])[F:15])=[CH:10][C:8]=2[N:9]=[C:18]=[S:19])[CH2:5][CH2:6]1

Participants

5

Reactant 2

HCID 10040ThiophosgeneHCID 136624N-(2-Amino-4-(trifluoromethyl)phenyl)morpholine

Product 1

HCID 18952335HCID 18952335, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

Reaction of 2-morpholino-5-trifluoromethylaniline (12 g) with thiophosgene (8.6 g) in dioxan (30 ml) and water (100 ml) at 0° C. for 30 minutes and then at room temperature for 2 hours yielded a residue which was extracted with dichloromethane to give 2-morpholino-5-trifluoromethylphenyl isothiocyanate as a yellow oil.

Workup

  1. customat room temperature for 2 hours yielded a residue which
  2. extractionwas extracted with dichloromethane

Sources & evidence

ORD record
ord-163ffffd5e094e588f17f7714f69374c
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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