HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophosgene → 5-Cyano-2-morpholinophenyl isothiocyanate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophosgene | HCID 10040 | — |
| Reactant | 3-Amino-4-(morpholin-4-yl)benzonitrile | HCID 18952270 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-Cyano-2-morpholinophenyl isothiocyanate | HCID 18952194 | — |
Reaction Steps
Reaction of 5-cyano-2-morpholinoaniline (2 g) with thiophosgene (1.15 ml) in dioxan (2 ml) and water (25 ml) at 0° C. for 30 minutes and then at room temperature for 2 hours yielded a residue which was extracted with dichloromethane to give 5-cyano-2-morpholinophenyl isothiocyanate as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05373008 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-c77904a4b98f4428ba8ffb88f9bdc51b |
| Source note | uspto-grants-1994_12 |