HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 1,1-Dimethyl-2-(5-cyano-2-morpholinophenyl)guanidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Lead diacetate trihydrate | HCID 22456 | — |
| Reactant | HCID 18952331 | HCID 18952331 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1,1-Dimethyl-2-(5-cyano-2-morpholinophenyl)guanidine | HCID 18952285 | — |
Reaction Steps
A mixture of 1-(5-cyano-2-morpholinophenyl)thiourea (5.2 g), potassium carbonate (8.3 g), a 33% ethanolic solution of dimethylamine (15 ml), lead acetate trihydrate and ethanol (25 ml) was heated under reflux for 3 hours to yield 1,1-dimethyl-2-(5-cyano-2-morpholinophenyl)guanidine (m.p. 125°-127° C.) which was converted into its monofumarate salt [m.p. 223°-225° C. (dec)] which was recrystallised from methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05373008 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-b23f264d92d54f898391c1b033801678 |
| Source note | uspto-grants-1994_12 |