HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophosgene → 5-Chloro-2-morpholinophenyl isothiocyanate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophosgene | HCID 10040 | — |
| Reactant | 5-Chloro-2-(morpholin-4-yl)aniline | HCID 846189 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-Chloro-2-morpholinophenyl isothiocyanate | HCID 18952098 | — |
Reaction Steps
Reaction of 4-(2-amino-4-chlorophenyl)morpholine (8.5 g) with thiophosgene (4.6 ml) in dioxan (25 ml) and water (100 ml) for 30 minutes at 0° C. and for 3 hours at room temperature gave 5-chloro-2-morpholinophenyl isothiocyanate as a pale yellow solid (m.p. 86°-87° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05373008 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-9bd12e691fb1486f8dce6eae5b0f9dea |
| Source note | uspto-grants-1994_12 |