Thiophosgene → HCID 18952287, compound

HRID 1492287Notes

Reaction equation

HRID 1492287 reaction equation
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[C:15](Cl)(Cl)=[S:16]>O1CCOCC1.O>[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[C:4]([N:5]=[C:15]=[S:16])[CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 2

HCID 10040ThiophosgeneHCID 18952264HCID 18952264, compound

Product 1

HCID 18952287HCID 18952287, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

Reaction of 3-methyl-2-morpholinoaniline (9.4 g) with thiophosgene (6 ml) in dioxane (50 ml) and water (200 ml) at 0° C. for 30 minutes and at room temperature for 2 hours gave a product which was extracted with dichloromethane to give 3-methyl-2-morpholinophenyl isothiocyanate as a red oil.

Workup

  1. customat room temperature for 2 hours gave a product which
  2. extractionwas extracted with dichloromethane

Sources & evidence

ORD record
ord-4b10dd1467134502ac9c26b809197d3a
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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