Thiophosgene → HCID 18952329, compound

HRID 1492291Notes

Reaction equation

HRID 1492291 reaction equation
[CH3:1][O:2][C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[C:5]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:4]=1.[C:16](Cl)(Cl)=[S:17]>O1CCOCC1.O>[CH3:1][O:2][C:3]1[CH:9]=[CH:8][C:6]([N:7]=[C:16]=[S:17])=[C:5]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:4]=1

Participants

5

Reactant 2

HCID 10040ThiophosgeneHCID 18952250HCID 18952250, compound

Product 1

HCID 18952329HCID 18952329, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

Reaction of 4-methoxy-2-morpholinoaniline (4.7 g) and thiophosgene (2.9 ml) in dioxan (25 ml) and water (75 ml) for 30 minutes at 0° C. and 3 hours at room temperature yielded a residue which was extracted with dichloromethane to give 4-methoxy-2-morpholinophenyl isothiocyanate as an oil.

Workup

  1. custom3 hours at room temperature yielded a residue which
  2. extractionwas extracted with dichloromethane

Sources & evidence

ORD record
ord-9e3955d2fb804a63a4cabc547dcc85f7
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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