Butylamine → HCID 178449171, compound

HRID 1492296Notes

Reaction equation

HRID 1492296 reaction equation
[CH3:1][N:2]=[C:3]=[N:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1.[CH2:17]([NH2:21])[CH2:18][CH2:19][CH3:20]>C(O)(C)(C)C>[CH2:17]([NH:21][C:3]([NH:2][CH3:1])=[N:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)[CH2:18][CH2:19][CH3:20]

Participants

4

Reactant 2

HCID 8007ButylamineHCID 15746469N-methyl-N'-(2-morpholinophenyl)carbodiimide

Product 1

HCID 178449171HCID 178449171, compound

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

A mixture of N-methyl-N'-(2-morpholinophenyl)carbodiimide (1 g), n-butylamine (0.5 g) and t-butanol (5 ml) was heated at 90°-95° C. for four hours. The solvent was removed by evaporation and the residue dissolved in dichloromethane (100 ml) and the resulting solution was washed with water, dried and filtered. Removal of the solvent gave 1-(n-butyl)-2-(2-morpholinophenyl)-3-methylguanidine which was converted into its monofumarate salt (m.p. 178°-179° C.).

Workup

  1. temperaturewas heated at 90°-95° C. for four hours
  2. customThe solvent was removed by evaporation
  3. dissolutionthe residue dissolved in dichloromethane (100 ml)
  4. washthe resulting solution was washed with water
  5. customdried
  6. filtrationfiltered
  7. customRemoval of the solvent

Sources & evidence

ORD record
ord-2a478b8d14234aa2881061184716c589
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

Loading…