反应详情

温度

100 °C

A mixture of 2-morpholinoaniline hydrochloride (19.2 g), m-cresol (80 ml) and dimethylcyanamide (9.45 g) was heated at 100° C. for five hours, cooled and added to a mixture of 40% aqueous sodium hydroxide solution (300 ml) and ice (300 g). Water (300 ml) was added and the resulting solid separated by filtration, washed with water and dissolved in dichloromethane. The solution was dried and the solvent removed to give a residue which was recrystallised from hexane to give 1,1-dimethyl-2-(2-morpholinophenyl)guanidine (m.p. 142°-143° C.).

1. temperaturecooled
2. customthe resulting solid separated by filtration
3. washwashed with water
4. dissolutiondissolved in dichloromethane
5. customThe solution was dried
6. customthe solvent removed
7. customto give a residue which
8. customwas recrystallised from hexane