Sodium Thiosulfate → HCID 86748315, compound

Participants

Reaction Steps

To a mixture of 9a (1.84 g, 8.28 mmol) and NaHCO3 (2.45 g, 29.2 mmol) in a mixture of CH2Cl2 (40mL) and water (17 mL) was added mCPBA (85%, 3.36 g, 16.5 mmol) in portionwise with stirring vigorously in an ice bath. The mixture 19 was stirred for 15 min. To the mixture were added water (16 mL), NaHCO3 (2.45 g) and mCPBA (1.68 g), and stirring was continued for 20 min. The excess amount of peracid was decomposed with Na2S2O3 solution in the presence of a catalytic mount of KI. The organic layer was separated, and the aqueous layer was extracted with EtOAc. The combined organic layers were washed with NaCl solution, and dried over Na2SO4. Filtration and concentration gave 2.69 g of 10a, as white solids, which was used in the next reaction without further purification.

Provenance & Evidence