2,6-Dichloropyridine → HCID 86748324, compound

Participants

Reaction Steps

3-Trifluoromethoxyphenol (19 g; 0.106 mol) was added to oil-free sodium hydride (2.7 g) in dry dimethylformamide (120 ml). 2,6-Dichloropyridine (8 g; 0.054 mol) was then added and the reaction mixture refluxed for 4 hours. The symmetrical phenoxy pyridine 2,6-di-[3-trifluoromethoxyphenoxy]-pyridine was isolated, following conventional work up, chromatography and distillation procedures, as a colorless oil (17 g; yield 73%). Boiling point: 145° C. at 3 mm Hg.

Provenance & Evidence