HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorophenol → HCID 18950233, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorophenol | HCID 9732 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Chloro-6-[3-(trifluoromethyl)phenoxy]pyridine | HCID 11011172 | — |
| Reactant | HCID 18950234 | HCID 18950234 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Chloroform water | HCID 22418719 | — |
| Product | HCID 18950233 | HCID 18950233 | — |
Reaction Steps
The procedure of a) above was followed using 4-fluorophenol (8 g; 0.07 mol) in dry dimethylformamide (20 ml), sodium hydride (2 g) also in dry dimethylformamide (60 ml), 2-(3-trifluoromethylphenoxy)-6-chloropyridine from a) above (19.5 g; 0.07 mol) with a 2 hour reflux. The asymmetrical phenoxypyridine 2-(3-trifluoromethylphenoxy)-6-(4-fluorophenoxy)pyridine (18.9 g; 76%) was derived as a colorless oil from the organic layer of chloroform/water (500 ml; 50/50) following solvent extraction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05374604 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-e7cae57763584781b7c8c5d5f71bec94 |
| Source note | uspto-grants-1994_12 |