反应详情

温度

100 °C

A mixture of methyl 4-bromo-2-(bromomethyl)benzoate (12 g) and sodium thiomethoxide (2.5 g) in toluene was stirred at 100° C. for 2 hours. The mixture was then cooled, poured into water and extracted with ethyl acetate. The organic layer was separated, washed with brine, dried (anhydrous sodium sulphate) and evaporated to afford a brown oil which was purified by column chromatography on silica gel giving methyl 4-bromo-2-(methylsulphenylmethyl)benzoate (4.1 g) as white crystals, m.p. 79.3° C.

1. temperatureThe mixture was then cooled
2. extractionextracted with ethyl acetate
3. customThe organic layer was separated
4. washwashed with brine
5. dry with materialdried (anhydrous sodium sulphate)
6. customevaporated
7. customto afford a brown oil which
8. customwas purified by column chromatography on silica gel