HCID 18657707, compound → HCID 10199152, compound

Participants

Reaction Steps

4N-Hydrochloric acid/dioxane (0.17 ml, 0.68 mmole) was added to a solution of 9-[(1R,2R,3S)-2,3-bis-(t-butyldiphenylsilyloxymethyl)-1-cyclopentyl]-adenine (129 mg, 0.17 mmole) in methanol (1 ml). After stirring the mixture at room temperature overnight, solvent was distilled off from the reaction mixture under reduced pressure, after which water was added to the residue, ether-soluble material was removed therefrom, the residual solution was neutralized with 0.1N solution of sodium hydroxide, and solvent was distilled off therefrom. The residue was purified by Diaion HP-20 column chromatography (methanol concentration gradient) to obtain 9-[(1R,2R,3S)-2,3-bis(hydroxymethyl)-1-cyclopentyl]-adenine (43 mg, Yield 94%).

Provenance & Evidence