Hydrochloric Acid → HCID 10660159, compound

Participants

Reaction Steps

Sodium methoxide (2.7 mg, 0.55 mole) was added to a solution of 9-[(1S,3S,4S)-3,4-bis(benzoyloxymethyl)cyclohexyl]-adenine (25 mg, 0.05 mole) in anhydrous methanol (2 ml) under cooling with ice. After stirring the mixture at room temperature overnight, the reaction mixture was neutralized with dilute hydrochloric acid and the solvent was distilled off under reduced pressure. Then, ethyl ether and water were added to the residue, the ethyl ether layer was removed, and the water was distilled off. Then, the residue was purified by Diaion HP-20 column chromatography (methanol concentration gradient) to obtain 9-[(1S,3S,4S)-3,4-bis(hydroxymethyl)-cyclohexyl]-adenine (9.4 mg, Yield 66.2%).

Provenance & Evidence