Cesium carbonate → HCID 18950398, compound

Participants

Reaction Steps

2-[4-(Bromomethyl)-1H-benzimidazol-1-yl]-benzonitrile (0.65 g, 2.08 mmol, prepared as described in part C of Example 8) and 2-butyl-4-chloro-1H-imidazole-5-carboxaldehyde (0.409 g, 2.19 mmol, prepared as described in part C of Example 5) were placed in 20.8 mL anhydrous dimethylformamide. Freshly ground cesium carbonate (1.02 g, 3.12 mmol) was then added and the reaction was stirred at room temperature for 16 hours. The reaction was then partitioned between ethyl acetate and water and the organic phase was washed with brine, dried and concentrated. The crude oil was purified by flash chromatography (SiO2, 80:20 hexane:acetone) to yield the title A compound (0.68 g) as a white solid.

Provenance & Evidence