Dichloromethane → 1-Chloro-2-methylpropyl 2,2-dimethylpropanoate

To freshly fused zinc chloride (27.3 mg) and trimethylacetylchloride (5.11 ml, 41.5 mmol) in methylene chloride(10 ml) at 10° C. was added isobutyraldehyde (freshly distilled) (3.77 ml, 41.5 mmol) dropwise, maintaining the temperature at <25° C. Once the addition was complete, the reaction was stirred for one hour at room temperature. The reaction mixture was then washed with 20% NaOAc, dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo to give the title A compound (3.25 g) as a clear liquid.

1. distillationfreshly distilled) (3.77 ml, 41.5 mmol) dropwise
2. temperaturemaintaining the temperature at <25° C
3. additionOnce the addition
4. washThe reaction mixture was then washed with 20% NaOAc
5. dry with materialdried over anhydrous magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated in vacuo

ORD record

ord-1ba397f515244fa79781508aae6583cf

Source dataset

uspto-grants-1994_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05374615