反应详情

温度

10 °C

To freshly fused zinc chloride (41 mg) in methylene chloride (10 ml) was added propionyl chloride (5.0 g, 54.0mmol). The reaction was cooled to 10° C. and isobutyraldehyde (3.89 g, 54.0 mmol) was added dropwise maintaining the temperature at 25° C. Once the addition was complete, the reaction Was Stirred for one hour at room temperature. The reaction mixture was washed with 20% NaOAc and the organic phase was concentrated in vacuo to provide the title A compound.

1. temperaturemaintaining the temperature at 25° C
2. additionOnce the addition
3. washThe reaction mixture was washed with 20% NaOAc
4. concentrationthe organic phase was concentrated in vacuo
5. customto provide the title A compound