Dichloromethane → 1-Chloro-2-methylpropyl propanoate

HRID 1492493Notes

Reaction equation

HRID 1492493 reaction equation
[C:1]([Cl:5])(=[O:4])[CH2:2][CH3:3].[CH:6](=[O:10])[CH:7](C)[CH3:8].[CH2:11](Cl)Cl>>[C:6]([O:4][CH:1]([Cl:5])[CH:2]([CH3:11])[CH3:3])(=[O:10])[CH2:7][CH3:8]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6561IsobutyraldehydeHCID 62324Propionyl chloride

Product 1

HCID 126610101-Chloro-2-methylpropyl propanoate

Conditions

Temperature
10 °C

Procedure

To freshly fused zinc chloride (41 mg) in methylene chloride (10 ml) was added propionyl chloride (5.0 g, 54.0mmol). The reaction was cooled to 10° C. and isobutyraldehyde (3.89 g, 54.0 mmol) was added dropwise maintaining the temperature at 25° C. Once the addition was complete, the reaction Was Stirred for one hour at room temperature. The reaction mixture was washed with 20% NaOAc and the organic phase was concentrated in vacuo to provide the title A compound.

Workup

  1. temperaturemaintaining the temperature at 25° C
  2. additionOnce the addition
  3. washThe reaction mixture was washed with 20% NaOAc
  4. concentrationthe organic phase was concentrated in vacuo
  5. customto provide the title A compound

Sources & evidence

ORD record
ord-d9f9fa9ec5b44207b7b95166f00083cb
Source dataset
uspto-grants-1994_12
Patent number
US05374615

Reaction notes

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