HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → (RS)-2-bromo-2-(3-chlorophenyl)acetyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | (3-Bromophenyl)acetic acid | HCID 74653 | — |
| Reactant | Bromo-4-chlorophenylacetyl chloride | HCID 12575778 | — |
| Reactant | 2-Bromo-2-(3-bromophenyl)acetyl chloride | HCID 18951135 | — |
| Product | (RS)-2-bromo-2-(3-chlorophenyl)acetyl chloride | HCID 18951149 | — |
Reaction Steps
(RS)-2-Bromo-2-(3-bromophenyl)acetyl chloride may be prepared by the method described in Example 9 for the preparation of (RS)-2-bromo-2-(4-chlorophenyl)acetyl chloride, but using 5 g of 2-(3-bromophenyl)acetic acid, 2.8 cm3 of thionyl chloride and 1.5 cm3 of bromine as starting materials. 7 g of (RS)-2-bromo-2-(3-chlorophenyl)acetyl chloride are then obtained, which is used as such for the following step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05374656 |
| Source dataset | uspto-grants-1994_12 |
| ORD ID | ord-8e38841bd34248ed8865609222e70eee |
| Source note | uspto-grants-1994_12 |