HCID 18950742, compound → HCID 18950695, compound

Participants

Reaction Steps

An appropriate amount of Raney nickel was suspended in 15 ml of saturated ammonical methanol solution, 0.54 g of 3-(4-methoxymethyloxyphenyl)-3-(3-pyridyl)propionitrile was added to the suspension and the mixture was stirred for 18 hours under 15 atmospheric pressure in an atmosphere of hydrogen. The resulting reaction mixture was filtered and the filtrate was concentrated under a reduced pressure. The thus prepared residue was subjected to silica gel column chromatography to obtain 0.49 g of 3-(4-methoxymethyloxyphenyl)-3-(3-pyridyl)propylamine from ammonia water-methanol-chloroform (1:10:100 v/v) eluate fraction.

Provenance & Evidence